The hotel is located in the center of the city and is within walking distance of the Plaza Mayor, the historical center, the university, the cathedral, and other popular sites. Guests staying at the Catalonia Plaza Mayor Salamanca will find that they can also find shopping areas, dining establishments, and more in the area. Guests can walk to many locations from the front door of the Catalonia Plaza Mayor Salamanca. They will be able to take taxis and other forms of public transportation to reach other areas.

Guests at the Catalonia Plaza Mayor Salamanca will find that the rooms include many amenities such as cable TV, bathrooms, mini bars, air conditioning, phones, alarm clocks, in room safes, hairdryers, and more.

The hotel opened in 2002 and offers breakfast for guests. The Catalonia Plaza Mayor Salamanca also has an onsite restaurant that serves international cuisine and a bar where guests will be able to have a drink and relax after a day of exploring the city. Those traveling on business will find that the hotel offers meeting facilities.